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. 2021 Feb 6;13(4):653. doi: 10.3390/cancers13040653

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Experimental set-up for live tissue fluorescence imaging. An optical fiber (i) delivers light excitation through a gradient index (GRIN) lens imaging probe (ii) into a tissue sample (not shown). The resultant fluorescent signal is captured by an external charge-coupled device (CCD) optical detector (iv) for 2-color fluorescence imaging. 4-axis (x, y, z linear and rotational) stage system (v) allows precise positioning of the imaging probe within the tissue sample. (b) GRIN lens imaging probe tip with triangular prism for side-viewing. (c) Imaging probe is placed through the microdevice into live murine tumoral tissue to image fluorescent drug and assay signal.