Figure 2.

Current and future anti-atherogenic therapies. Established atherogenic risk factors and processes are depicted in green bars and the current available and experimental therapies to counteract these atherogenic processes are depicted in the neighbouring bars. Current anti-atherogenic therapies successfully preclude hypertension, dyslipidaemia, inflammation, and thrombosis, however, endothelial dysfunction is not specifically targeted therapeutically. In this review we explain that the therapeutic targeting of the epigenetic enzymes EZH2 and SIRT1 mitigates endothelial cell activation and dysfunction and may block atherogenesis.