Table A2.

The extracted hazards ratios of Progression-free survival and overall survival to proceed meta-analysis.

	Participants			Overall Survival			Progression–Free Survival
Study ID	Total	Afatinib	Control	Hazard Ratio	95% Confidence Interval	p–Value	Hazard Ratio	95% Confidence Interval	p–Value
[22]	585	390	195	1.08	0.86–1.35	0.74	0.38	0.31–0.48	0.0001
[23]	345	229	111	1.12	0.73–1.73	0.60	0.58	0.43–0.78	0.0010
[30]	121	61	60	1.06	0.70–1.62	0.78	0.93	0.62–1.38	0.7100
[24]	364	242	122	0.95	0.68–1.33	0.76	0.26	0.19–0.36	0.0001
[32]	483	322	161	0.96	0.77–1.19	0.70	0.80	0.65–0.98	0.0300
[25]	795	398	397	0.81	0.69–0.95	0.01	0.81	0.69–0.96	0.0103
[26]	319	160	159	0.87	0.66–1.15	0.33	0.73	0.57–0.95	0.0170
[31]	340	228	112	0.88	0.68–1.13	0.32	0.63	0.48–0.82	0.0005