Table 1.
Non-synonymous Substitutions (dN) of Medium–High Frequency in the Global Population of SARS-CoV-2.
| Nucleotide Change | Amino Acid Change | Genomic Location |
dN/dS (p Value) |
Distribution and Frequency (%) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| US | LA | EU | AF | AS | OC | Global | ||||
| C1059T | T85I | ORF1a (nsp2) | 5.89 (0.009) |
49.2 | 12.5 | 9.80 | 5.80 | 2.40 | 11.4 | 14.41 |
| A1163T | I120F | ORF1a (nsp2) |
4.79 (0.052) |
0.00 | 0.00 | 0.20 | 0.00 | 11.4 | 43.2 | 10.08 |
| C14408T | P323L | ORF1b (nsp12) | 7.49 (0.002) |
80.6 | 92.3 | 81.8 | 88.4 | 68.2 | 81.1 | 79.58 |
| A23403G | D614G | S gene | 2.42 (0.153) |
80.3 | 90.9 | 85.3 | 92.6 | 69.0 | 81.1 | 80.80 |
| G25563T | Q57H | ORF3 | 7.13 (0.105) |
59.8 | 18.7 | 21.1 | 18.6 | 25.9 | 16.2 | 27.47 |
| G28881A | R203K | N gene | −0.43 (0.805) |
7.90 | 41.8 | 34.2 | 48.8 | 26.9 | 54.0 | 33.44 |
| G28883C | G204R | N gene | 1.79 (0.285) |
7.90 | 41.8 | 34.0 | 48.3 | 26.7 | 54.0 | 33.30 |
Abbreviations: US, United States of America; LA, Latin America; EU, Europe; AF, Africa; AS, Asia; OC, Oceania.