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. 2021 Feb 9;10(2):184. doi: 10.3390/pathogens10020184

Table 1.

Non-synonymous Substitutions (dN) of Medium–High Frequency in the Global Population of SARS-CoV-2.

Nucleotide Change Amino Acid Change Genomic Location dN/dS
(p Value)
Distribution and Frequency (%)
US LA EU AF AS OC Global
C1059T T85I ORF1a (nsp2) 5.89
(0.009)
49.2 12.5 9.80 5.80 2.40 11.4 14.41
A1163T I120F ORF1a
(nsp2)
4.79
(0.052)
0.00 0.00 0.20 0.00 11.4 43.2 10.08
C14408T P323L ORF1b (nsp12) 7.49
(0.002)
80.6 92.3 81.8 88.4 68.2 81.1 79.58
A23403G D614G S gene 2.42
(0.153)
80.3 90.9 85.3 92.6 69.0 81.1 80.80
G25563T Q57H ORF3 7.13
(0.105)
59.8 18.7 21.1 18.6 25.9 16.2 27.47
G28881A R203K N gene −0.43
(0.805)
7.90 41.8 34.2 48.8 26.9 54.0 33.44
G28883C G204R N gene 1.79
(0.285)
7.90 41.8 34.0 48.3 26.7 54.0 33.30

Abbreviations: US, United States of America; LA, Latin America; EU, Europe; AF, Africa; AS, Asia; OC, Oceania.