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. 2021 Feb 5;14(2):122. doi: 10.3390/ph14020122

Table 1.

The old recommendations and new possibilities for the use of metformin.

Approved to Treat No Formal Indication
(Used Off-Label)
Investigated for New
Applications
T2DM Prediabetes/obesity Cardioprotection
T1DM Nephroprotection
GDM Cancer
PCOS Anti-aging
NAFLD COVID-19