Table 1.
The IC50 values (mean ± SD) for all analyzed zinc complexes for human fibroblasts and keratinocytes. The IC50 was calculated using the Hill Equation after the viable cell number was normalized relative to untreated cells.
| IC50 Values (Mean ± SD) | ||
|---|---|---|
| Analyzed Complexes | Fibroblasts | Keratinocytes |
| ZnGlu (1) | 87.38 ± 6.01 c* | 231.17 ± 15.94 d |
| ZnGly (2) | 119.85 ± 4.61 b | 138.20 ± 8.11 be |
| ZnHis (3) | 171.48 ± 17.02 a | 102.00 ± 3.76 ac |
| ZnPro (4) | 172.20 ± 4.00 a | 157.20 ± 8.19 b |
| ZnMet (5) | - | - |
| ZnTrp (6) | 94.88 ± 8.41 c | 85.66 ± 14.28 c |
| ZnPCA ** | 171.73 ± 9.69 a | 102.50 ± 2.07 ac |
| ZnCl2 ** | 162.65 ± 4.10 a | 126.97 ± 4.32 ae |
- not detected because of too little solubility in culture medium; * means signed with the same letter within each column are not significantly different (Kruskal–Wallis test; p ≤ 0.05); ** reference compounds (ZnPCA: zinc 2-pirrolidone 5-carboxylate).