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. 2021 Feb 8;22(4):1684. doi: 10.3390/ijms22041684

Figure 4.

Figure 4

Loss of apical microvilli and flattened RPE in one-year-old NFE2L2/PGC-1α dKO mice as compared with their age-matched wild-type (WT) littermates. Panel 4 A shows the apical portion of WT RPE, where microvilli (arrowhead) are arranged normally, surrounding the photoreceptor outer segments (POS). In contrast, many of the apical portion of RPEs from dKO mice showed loss of apical microvilli: only a few microvilli on the apical surface were evident (B; arrow), with an increased density of melanin granules. Total RPE height from TEM graphs was measured in the region located 300 µm from the optic nerve head (C). Combined results from n = 6 animals, ** p < 0.001 (Mann-Whitney U-test). Scale bars: 1 µm (A,B).