De novo transcriptome of Hydrophis curtus venom glands: (A) Overview profile of all-transcript expression. (B) Profiling of toxin transcripts by gene families. Abbreviations: S-3FTx, short three-finger toxin; L-3FTx, long three-finger toxin; NC-3FTx, non-conventional three-finger toxin; PLA2, phospholipase A2; CRiSP, cysteine-rich secretory protein; PLA2I, phospholipase A2 inhibitor; Snaclec, snake venom C-type lectin/lectin-like protein; KSPI, Kunitz-type serine protease inhibitor; SVMP, snake venom metalloproteinase; CYS, cystatin; DPP IV, dipeptidylpeptidase IV; SVSP, snake venom serine protease; 5′NUC, 5′ nucleotidase; VEGF, vascular endothelial growth factor; HYA, hyaluronidase; PDE, phosphodiesterase; WAP, waprin; NP, natriuretic peptide; CVF, cobra venom factor; NGF, nerve growth factor; AP, aminopeptidase; LAAO, L-amino acid oxidase; and AChE, acetylcholinesterase. The expression of 5′NUC, VEGF, HYA, PDE, WAP, NP, CVF, NGF, AP, neprilysin, LAAO and AChE were each <0.01% of total toxin FPKM.