Table 2.
Overview of toxin genes in venom-gland transcriptome of Malaysian Hydrophis curtus.
| Toxin Family/ID | UniProt Accession Code | Species | Expression Abundance (%) |
|---|---|---|---|
| Three-Finger Toxin (3FTx) | 77.26 | ||
| S-3FTX | 56.48 | ||
| Short neurotoxin SN160 | Q8UW27 | H. hardwickii | 56.43 |
| Short neurotoxin homolog NTL4 | Q9YGI8 | B. multicinctus | <0.01 |
| Short neurotoxin OH-35 | Q53B49 | O. hannah | <0.01 |
| 3FTx | C6JUP5 | M. corallinus | <0.01 |
| putative three-finger toxin precursor | F5CPD1 | M. altirostris | <0.01 |
| Short neurotoxin OH-26 | Q53B52 | O. hannah | <0.01 |
| Cytotoxin homolog 5V | Q9W716 | Naja atra | 0.02 |
| Cytotoxin homolog 5 | Q91137 | Naja atra | 0.01 |
| Cytotoxin A5 | P62375 | Naja atra | 0.01 |
| Cardiotoxin-like protein BMLCL | Q9PW19 | B. multicinctus | <0.01 |
| L-3FTX | 20.78 | ||
| Long neurotoxin 2 | A3FM53 | H. hardwickii | 20.74 |
| Alpha-bungarotoxin isoform A31 | P60615 | B. multicinctus | 0.02 |
| Kappa-bungarotoxin | P01398 | B. multicinctus | 0.01 |
| Long neurotoxin homolog NTL2 | Q9YGH9 | B. multicinctus | 0.01 |
| Long chain neurotoxin 6 | U3FYQ0 | M. fulvius | <0.01 |
| Neurotoxin BM10-1-like | Q70WS8 | B. multicinctus | <0.01 |
| Long chain neurotoxin 2 | U3FAC0 | M. fulvius | <0.01 |
| NC-3FTX | <0.01 | ||
| Weak toxin 1 | Q8AY51 | B. candidus | <0.01 |
| Phospholipase A2 | 18.88 | ||
| Basic phospholipase A2 73 | Q8UW30 | H. hardwickii | 18.84 |
| Acidic phospholipase A2 | P00606 | B. multicinctus | 0.03 |
| Phospholipase A2 MALT0035C | F5CPF1 | M. altirostris | 0.01 |
| Phospholipase A2 GL16-1 | Q8JFB2 | L. semifasciata | <0.01 |
| Basic phospholipase A2 beta-bungarotoxin A1 chain | P00617 | B. multicinctus | <0.01 |
| Phospholipase A2 pkP2 | Q8JFG2 | L. semifasciata | <0.01 |
| Cysteine-rich Secretory Protein | 3.34 | ||
| Cysteine-rich venom protein 2 | Q8UW11 | H. hardwickii | 3.34 |
| Cysteine-rich secretory protein Bc-CRPb | F2Q6G2 | B. candidus | 0.01 |
| Phospholipase A2 Inhibitor | 0.13 | ||
| phospholipase A2 inhibitor-like | A0A6J1W4V4 | N. scutatus | 0.13 |
| C-type Lectin | 0.12 | ||
| C-type lectin 1 | A3FM55 | H. hardwickii | 0.07 |
| C-type lectin isoform 1 | H8PG89 | P. nigriceps | 0.04 |
| Venom C-type lectin mannose binding isoform 4 | D2YVK4 | H. stephensii | 0.01 |
| Kunitz-type Protease Inhibitor | 0.09 | ||
| Putative Kunitz-type serine protease inhibitor | B2BS84 | A. labialis | 0.06 |
| Kunitz-type protease inhibitor 1 | V8N7R6 | O. hannah | 0.01 |
| Kunitz-type serine protease inhibitor homolog beta-bungarotoxin B1 chain | Q8AY46 | B. candidus | 0.01 |
| Kunitz-type serine protease inhibitor PILP-2 | B4ESA3 | B. multicinctus | 0.01 |
| Kunitz-type serine protease inhibitor spermatin | C1IC52 | W. aegyptia | <0.01 |
| Kunitz-type serine protease inhibitor 28 | F8J2F3 | D. coronoides | <0.01 |
| Protease inhibitor 4 | C1IC53 | W. aegyptia | <0.01 |
| Kunitz-type serine protease inhibitor vestiginin-2 | A6MFL2 | D. vestigiata | <0.01 |
| Kunitz-type serine protease inhibitor | P20229 | Naja naja | <0.01 |
| Kunitz-type serine protease inhibitor 161 | F8J2F4 | D. coronoides | <0.01 |
| Snake Venom Metalloproteinase | 0.08 | ||
| Zinc metalloproteinase-disintegrin-like NaMP | A8QL59 | N. atra | 0.05 |
| Porphyriacase-1 | B5KFV2 | P. porphyriacus | 0.01 |
| Scutatease-1 | B5KFV7 | N. scutatus | 0.01 |
| Zinc metalloproteinase-disintegrin-like BmMP | A8QL49 | B. fasciatus | <0.01 |
| Zinc metalloproteinase-disintegrin-like MTP9 | F8RKV9 | D. coronoides | <0.01 |
| Carinatease-1 | B5KFV1 | T. carinatus | <0.01 |
| Snake venom metalloproteinase-disintegrin-like mocarhagin | Q10749 | N. mossambica | <0.01 |
| Zinc metalloproteinase-disintegrin-like BfMP | A8QL48 | B. fasciatus | <0.01 |
| Zinc metalloproteinase-disintegrin-like NaMP | A8QL59 | N. atra | <0.01 |
| Stephensease-1 | B5KFV4 | H. stephensii | <0.01 |
| Cystatin | 0.06 | ||
| Cystatin | E3P6N8 | P. australis | 0.03 |
| Cystatin | V8NX38 | O. hannah | 0.02 |
| Cystatin-B | V8P5H9 | O. hannah | 0.01 |
| Dipeptidyl Peptidase IV | 0.02 | ||
| Venom dipeptidylpeptidase IV | A6MJI1 | T. carinatus | 0.02 |
| Snake Venom Serine Protease | 0.01 | ||
| Serine protease harobin | Q5MCS0 | H. hardwickii | 0.01 |
| 5’ Nucleotidase | <0.01 | ||
| 5’ nucleotidase | A6MFL8 | D. vestigiata | <0.01 |
| 5’-nucleotidase domain-containing protein 3 | V8P4R1 | O. hannah | <0.01 |
| 5’-nucleotidase | V8NYW9 | O. hannah | <0.01 |
| Vascular Endothelial Growth Factor | <0.01 | ||
| Vascular endothelial growth factor C | V8NCP7 | O. hannah | <0.01 |
| Hyaluronidase | <0.01 | ||
| Hyaluronidase | V8PHI0 | O. hannah | <0.01 |
| Hyaluronidase | V8PFK9 | O. hannah | <0.01 |
| Hyaluronidase | V8P1Z9 | O. hannah | <0.01 |
| Phosphodiesterase | <0.01 | ||
| 2’,5’-phosphodiesterase 12 | V8PEM5 | O. hannah | <0.01 |
| Waprin | <0.01 | ||
| Supwaprin-a | B5KGY9 | A. superbus | <0.01 |
| Natriuretic Peptide | <0.01 | ||
| Natriuretic peptide Oh-NP | D9IX98 | O. hannah | <0.01 |
| Natriuretic peptide Na-NP | D9IX97 | N. atra | <0.01 |
| Cobra Venom Factor | <0.01 | ||
| A.superbus venom factor 1 | Q0ZZJ6 | A. superbus | <0.01 |
| Nerve Growth Factor | <0.01 | ||
| NGF-Hop-5 | R4G2H9 | H. bungaroides | <0.01 |
| Venom nerve growth factor 1 | Q3HXY6 | N. scutatus | <0.01 |
| Aminopeptidase | <0.01 | ||
| Aminopeptidase N | V8NGF6 | O. hannah | <0.01 |
| Neprilysin | <0.01 | ||
| Neprilysin | V8NQ76 | O. hannah | <0.01 |
| L-amino-acid Oxidase | <0.01 | ||
| L-amino-acid oxidase | A8QL51 | B. multicinctus | <0.01 |
| Acetylcholinesterase | <0.01 | ||
| Acetylcholinesterase | Q92035 | B. fasciatus | <0.01 |
Genus abbreviation: A, Austrelaps; B, Bungarus; Demansia/Drysdalia; H, Hydrophis/Hoplocephalus; M, Micrurus; N, Naja/Notechis; O, Ophiophagus; P, Pseudechis/Parasuta; T, Tropidechis; W, Walterinnesia.