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. 2021 Feb 5;22(4):1611. doi: 10.3390/ijms22041611

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The use of azobenzene-based crosslinker to construct light-responsive bicyclic peptides (adapted from [46]). (a) A tridentate hydroxyl amine/dichlorobenzene-containing azobenzene (HADCAz) crosslinker. (b). Ultraviolet (UV) light-induced reversible geometric (configurational) isomerization of azobenzene (Azb). (c) Sequential bicyclization of N-terminally glyoxal-functionalized peptide with the HADCAz crosslinker. TCEP—reducing agent tris(2-carboxyethyl)phosphine used to break the disulfide bond.