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. 2021 Feb 9;10(2):354. doi: 10.3390/cells10020354

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mechanisms of acquired resistance to first-line osimertinib that were identified in cell line models [32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,48,50,51,52,53,54,55,56,57,58,59,60]. This graph is color-coded by cell line models and mechanisms of resistance to first-line osimertinib. EGFR, epidermal growth factor receptor; AXL, AXL receptor tyrosine kinase; ERBB3, human epidermal growth factor receptor-3; IGF1R, insulin-like growth factor-1 receptor; TGF, transforming growth factor; ACK1, activated Cdc42-associated kinase-1; CDK4/6, cyclin-dependent kinase; BCL-2, B-cell lymphoma-2; YAP, yes-associated protein; ANKRD1, ankyrin repeat domain-1; IRE1α, inositol-requiring enzyme-1α.