Table 3.
COVID-19 Test (Nasopharyngeal) | SARS-CoV-2 Antibodies § (Serum) |
|
---|---|---|
Patient 1 | ||
Day 8 * | Positive | n.a. |
~Day 40 * | n.a. | n.a. |
~Day 100 * | n.a. | Negative |
Patient 2 | ||
Day -2 (before COVID-19 symptom onset) | Negative | |
Day 40 * | n.a. | Positive IgG (19.4 U/mL) and IgA (15.2 U/mL) SARS-CoV-2-nucleocapside, Positive IgG SARS-CoV-2-spike (18.3 U/mL), Positive IgG SARS-CoV-2-RBD (19.9 U/mL) |
Day 100 * | n.a. | Negative |
Patient 3 | ||
Day -2 (before COVID-19 symptom onset) | Negative | n.a |
Day 40 * | n.a. | n.a. |
Day 100*,1 | n.a. | Positive IgG (59.3 U/mL) and IgA (28.6 U/mL) SARS-CoV-2-nucleocapside |
Patient 4 | ||
Day 2* | Positive | n.a. |
Day 40* | n.a. | n.a. |
Day 100* | n.a. | Negative |
Abbreviations: n.a.: not available; * after COVID-19 symptom onset; 1 five days after canakinumab increase (300 mg/q4w), § Antibody against SARS-CoV-2-spike, SARS-CoV-2-RBD, SARS-CoV-2-nucleocapside, Reference values: SARS-CoV-2-nucleocapside: IgG >11.0 U/mL, IgA >4.4 U/mL; SARS-CoV-2-spike: IgG >15.0 U/mL, IgA >6.0 U/mL, SARS-CoV-2-spike-RBD: IgG >15.0 U/mL, IgA >14.0 U/mL.