. 2021 Feb 5;22(4):1624. doi: 10.3390/ijms22041624

Table 2.

Summary of microRNAs (miRNAs) regulating pancreatic cancer stem cell (CSC) growth and/or stemness.

miRNA	Expression in CSCs	Relation to Stemness	Reference
miR-15a	Downregulated	Targets BMI-1	[75]
miR-15a	Downregulated	5-FU-modified mimic promotes apoptosis, inhibits invasion and overcomes resistance in CSC ¹	[75]
miR-34	Downregulated	Targets c-Met	[74]
		Overexpression downregulates CD44 and CD133 and inhibits tumor formation in vivo
		Enhances sensitivity to docetaxel and gemcitabine ¹
miR-135b	Upregulated	Upregulated in CD44⁺/CD24⁺/ESA⁺ cells	[76]
miR-135b	Upregulated	Anti-miR-135b decreases expression of NANOG, ALDH1, SOX2 and OCT-4 in vitro and suppresses tumor growth in vivo ¹	[76]
miR-195	Downregulated	Targets DCLK1	[77]
miR-200a	Downregulated	Overexpression downregulates CD24, CD44, ESA, N-cadherin, ZEB1, and vimentin	[78,79]
miR-200a	Downregulated	Upregulated after DCLK1 knockdown	[78,79]
miR-205	Downregulated	Overexpression downregulates OCT-3/4, NANOG, CD44, and ALDH1	[80]
miR-1246	Upregulated	Upregulated in CD44⁺/CD24⁺ cells	[81]
miR-1246	Upregulated	Overexpression increases tumor sphere-forming capability and resistance to gemcitabine	[81]

¹ These miRNAs have demonstrated therapeutic potential.