. 2021 Feb 5;22(4):1624. doi: 10.3390/ijms22041624

Table 3.

Summary of microRNAs (miRNAs) regulating gastric cancer stem cell (CSC) growth and/or stemness.

miRNA	Expression in CSCs	Relation to Stemness	Reference
miR-26a	Downregulated	Targets HOXC9	[89]
miR-26a	Downregulated	Overexpression reduces self-renewal capacity of spheroid cells and invasive capacity	[89]
miR-106b	Upregulated	Upregulated in CD44⁺ cells	[87]
miR-106b	Upregulated	Targets SMAD7	[87]
miR-193-3p	Upregulated	Overexpression increases resistance to 5-FU and cisplatin¹	[90]
miR-196a-5p	Upregulated	Upregulated in CD44⁺ cells	[88]
miR-196a-5p	Upregulated	Targets SMAD4	[88]
miR-200a	Downregulated	Downregulated in ZEB1⁺ and Snail⁺, invasive cells	[91]
miR-200c	N/A	Delivery with micelle-based nanoparticles enhances sensitivity to radiotherapy ¹	[92]
miR-216a-3p	Downregulated	Downregulated by BRD4	[93]
miR-216a-3p	Downregulated	Targets Wnt3a	[93]
miR-524-5p	Downregulated	Enhances sensitivity to cisplatin ¹	[94]
miR-876-3p	Downregulated	Enhances sensitivity to cisplatin ¹	[95]
miR-876-3p	Downregulated	Targets SMAD4	[95]

¹ These miRNAs have demonstrated therapeutic potential.