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TPF and SHG images of keratin and collagen in 3D images of skin biopsies of healthy subject (A) and palmoplantar keratoderma (B). Penetration depth of the pump laser markedly decreases if the epidermis expands; thus, the papillary dermis could not be reached in the case of keratoderma. The size of the images as follows: 420 × 420 μm.
