Table 1.
Demographic and clinical features of the main cohort of patients with MS and control subjects.
| Patients’ Group | |||||
|---|---|---|---|---|---|
| Variable | Control Subjects | All Patients | CIS/RIS | RRMS | PMS |
| N | 20 | 166 | 25 | 117 | 24 |
| Age | 46.1 (29.7–53.3) | 39.8 (29.7–47.9) | 41.0 (32.9–42.9) | 35.6 (27.7–46.7) | 48.6 (39.6–55.5) |
| Gender: F | 7 (35.0%) | 57 (34.3%) | 6 (24%) | 38 (32.5%) | 13 (54.2%) |
| Oligoclonal Bandingy/n/NA | / | 27 (17.2%) | 10/14/1 (41.7%) | 15/95/7 (13.6%) | 2/21/1 (8.7%) |
| Disease activityy/n/NA | / | 81 (48.8%) | 10/14/1 (41.7%) | 67/43/7 (60.9%) | 4 (16.7%) |
| EDSS | / | 2.0 (1.0–3.0) | 1.0 (1.0–2.0) | 1.5 (1.0–3.0) | 3.5 (2.2–5.2) |
| Disease Duration | / | 12.4 (2.4–37.7) | 2.8 (1.6–4.7) | 12.9 (1.8–38.9) | 24.3 (12.3–61.3) |
| PI (T0) | / | 0.2 (0.0–0.6) | 0.6 (0.2–1.0) | 0.1 (0.0–0.6) | 0.2 (0.0–0.2) |
| let-7b-5p | 0.002 (0.001–0.009) | 0.004 (0.001–0.012) | 0.005 (0.001–0.010) | 0.005 (0.001–0.015) | 0.002 (0.001–0.003) |
| let-7e-5p | 0.003 (0.001–0.010) | 0.002 (0.001–0.006) | 0.002 (0.000–0.01) | 0.002 (0.001–0.006) | 0.004 (0.002–0.006) |
| let-7f-5p | 0.004 (0.003–0.007) | 0.004 (0.002–0.006) | 0.004 (0.003–0.007) | 0.004 (0.002–0.006) | 0.004 (0.002–0.005) |
Data are median and 25th-75th percentiles. Abbreviations: MS = Multiple Sclerosis; CIS/RIS = Clinically Isolated Syndrome/Radiologically Isolated Syndrome; RRMS = Relapsing-Remitting MS; PMS = Progressive MS; CSF = Cerebrospinal Fluid; EDSS = Expanded Disability Status Scale; F = Female; y/n/NA = yes/no/Not Available; PI(T0) = Progression Index at T0.