Table 3.

List of MSCs and MSC-derived products with content, sources for variations and comments regarding standardization.

Product	Content	Source of Variation	Comments
Stem cells (e.g., mesenchymal stem cells)	Viable cells	Donor, tissue source, composition of culture media, cell density, passage number, pre-culture conditions	Tissue source and pre-conditioning can be reported
Conditioned media	Soluble proteins, extracellular vesicles	As for stem cells plus culture time until collection, volume and composition of the collection medium	Isolation method can be standardized. There are no guidelines for characterization of the conditioned media
EVs/exosomes	Cytokines, growth factors, signaling lipids, mRNAs, regulatory miRs	As for conditioned media plus isolation method and storage condition of EVs	Recommendations for characterization of exosomes are available