Table 2.
Univariable and multivariable Cox regression.
| Univariable Cox Regression | Multivariable Cox Regression | |||||
|---|---|---|---|---|---|---|
| Variable | Hazard Ratio | 95% Confidence Interval | p-Value | Hazard Ratio | 95% Confidence Interval | p-Value |
| Age (>66 years) | 1.46 | 0.98–2.18 | 0.061 | 0.97 | 0.61–1.53 | 0.89 |
| Sex (male) | 0.82 | 0.55–1.22 | 0.32 | - | - | - |
| ECOG score | - | - | 0.074 | - | - | 0.22 |
| 0 | reference | reference | ||||
| 1 | 1.41 | 0.89–2.24 | 0.14 | 1.32 | 0.81–2.14 | 0.27 |
| 2 | 4.0 | 0.95–16.84 | 0.059 | 3.08 | 0.70–13.48 | 0.14 |
| Charlson comorbidity index (CCI) | 0.93 | 0.81–1.07 | 0.33 | - | - | - |
| Primary tumor location | - | - | 0.014 | - | - | 0.09 |
| Gastrointestinal | reference | reference | ||||
| Pancreatic | 1.8 | 1.11–2.94 | 0.018 | 1.51 | 0.92–2.47 | 0.11 |
| Pulmonary | 2.62 | 1.30–5.28 | 0.007 | 1.81 | 0.88–3.72 | 0.10 |
| CUP | 1.08 | 0.61–1.94 | 0.79 | 0.79 | 0.43–1.46 | 0.45 |
| Metastatic spread | ||||||
| Hepatic | 0.59 | 0.26–1.35 | 0.21 | - | - | - |
| Lymphonodal | 1.33 | 0.74–2.40 | 0.34 | - | - | - |
| Osseous | 0.93 | 0.62–1.39 | 0.72 | - | - | - |
| Peritoneal | 1.17 | 0.73–1.87 | 0.51 | - | - | - |
| Pulmonary | 1.05 | 0.43–2.58 | 0.92 | - | - | - |
| Functionality | 0.83 | 0.55–1.26 | 0.39 | - | - | - |
| Hedinger syndrome | 1.35 | 0.55–3.33 | 0.52 | - | - | - |
| De Ritis ratio (>0.927) | 1.89 | 1.19–3.0 | 0.007 | 1.7 | 1.01–2.86 | 0.047 |
| CgA (>204 μg/L) | 2.16 | 1.35–3.46 | 0.001 | 2.05 | 1.24–3.39 | 0.005 |