Table 3.

Experimental runs, independent variables and measured responses, particle size, and zeta potential of acetazolamide and carvedilol niosomes formulae, n = 3.

Formula	A: Surfactant Type	B: Surfactant to CHO	Entrapment Efficiency (%EE)	Particle Size (nm)	Zeta Potential
A-S20-C6	Span 20	7:6	93.53 ± 0.15	628.95 ± 0.64	34.17 ± 0.58
C-S20-C6		7:6	92.55 ± 0.25	682.25 ± 0.34	33.22 ± 0.09
A-S20-C4		7:4	92.99 ± 0.77	467.85 ± 0.92	33.66 ± 0.58
C-S20-C4		7:4	92.43 ± 0.24	481.75 ± 0.64	39.33 ± 0.32
A-S60-C6	Span 60	7:6	97.75 ± 0.10	419.85 ± 0.63	69.39 ± 0.77
C-S60-C6		7:6	95.95 ± 0.13	416.40 ± 0.48	61.12 ± 0.36
A-S60-C4		7:4	96.82 ± 0.18	543.70 ± 0.98	50.94 ± 0.16
C-S60-C4		7:4	95.64 ± 0.27	477.25 ± 0.27	54.12 ± 0.80
A-T20-C6	Tween 20	7:6	91.03 ± 0.07	749.55 ± 0.33	28.54 ± 0.59
C-T20-C6		7:6	91.49 ± 0.32	633.80 ± 0.84	33.51 ± 0.65
A-T20-C4		7:4	93.59 ± 0.53	877.40 ± 0.11	33.16 ± 0.88
C-T20-C4		7:4	93.14 ± 0.54	815.55 ± 0.75	23.49 ± 0.38
A-T60-C6	Tween 60	7:6	90.54 ± 0.22	767.90 ± 0.85	31.15 ± 0.88
C-T60-C6		7:6	90.23 ± 0.06	732.60 ± 0.39	22.04 ± 0.33
A-T60-C4		7:4	91.00 ± 0.23	882.05 ± 0.34	19.86 ± 0.54
C-T60-C4		7:4	91.57 ± 0.35	840.65 ± 0.75	37.92 ± 0.61
A+C-S20-C6	Span 20	7:6	94.25 ± 0.33	459.59 ± 0.42	57.83 ± 0.34
A+C-S20-C4		7:4	94.53 ± 0.33	453.90 ± 0.35	58.73 ± 0.50
A+C-S60-C6	Span 60	7:6	97.91 ± 0.53	414.30 ± 0.23	72.04 ± 0.43
A+C-S60-C4		7:4	94.94 ± 0.06	434.21 ± 0.19	61.12 ± 0.70
A+C-T20-C6	Tween 20	7:6	92.51 ± 0.22	720.10 ± 0.53	43.31 ± 0.55
A+C-T20-C4		7:4	92.61 ± 0.37	757.30 ± 0.12	43.26 ± 0.32
A+C-T60-C6	Tween 60	7:6	91.90 ± 0.35	882.05 ± 0.34	39.26 ± 0.70
A+C-T60-C4		7:4	92.71 ± 0.45	840.65 ± 0.75	39.98 ± 0.55

Presented values are mean ± SD.