Table 4.
Permeation parameters of in vitro release profiles of ACZ and CAR loaded niosomes formulations through membrane compare to their solution.
| Niosomes | Mucoadhesive Polymer |
Cumulative Amount Permeated/Area at 24 h (µg/cm2) mean ± SD |
Flux (Jss) (µg/cm2/h) |
Permeability Coefficient (Kp) (cm/h) |
Lag Time (tlag) (min.) |
|---|---|---|---|---|---|
| A-S60-C6 | - | 607.96 ± 30.33 | 53.28 ± 0.04 | 0.01 ± 0.45 | 4.23 ± 0.31 |
| C-S60-C6 | - | 523.04 ± 34.03 | 54.43 ± 8.21 | 0.02 ± 0.25 | 4.76 ± 0.82 |
| A+C-S60-C6 | - | 706.17 ± 30.33 | 72.96 ± 1.01 | 0.01 ± 0.43 | 3.53 ± 0.39 |
| H-LV A+C-S60-C6 | HPMC-LV | 1370.75 ± 85.12 | 145.02 ± 4.05 | 0.02 ± 0.29 | 2.53 ± 0.11 |
| Combination ACZ and CAR Solution |
- | 393.07 ± 04.03 | 44.43 ± 4.21 | 0.02 ± 0.31 | 4.96 ± 0.92 |
Each value is an average of three determinations (n = 3).