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Differentially abundant proteins in S-EVs from ALCL samples and healthy donors. (a) Principal component analysis performed on abundance levels of 277 identified proteins distinguishes ALCL from healthy donor (HD) S-EVs. (b) Heatmap of the 50 proteins overrepresented in ALCL S-EVs, ordered by decreasing log2fold change (LFC). Unsupervised hierarchical clustering revealed that ALCL S-EV samples have a unique protein expression profile, distinct from HD.
