Table 2.
Fecal metabolite changes with respect to healthy controls in women with restrictive anorexia nervosa (ANR) and binge-purging anorexia nervosa (ANBP).
| Metabolite | HMDB Code | ANR | ANBP | Selection Criteria |
|---|---|---|---|---|
| Acetic acid | HMDB0000042 | ↓ | ↑ | PLS-DA-2classes |
| Allose | HMDB0001151 | ↓ | ↑ | ANOVA |
| alpha-ketoisovaleric acid | HMDB0000019 | ↓ | ↑ | PL-SDA-3classes |
| Arabinose | HMDB0029942 | ↓ | ↓↓ | PLS-DA-3classes, PLS-DA-2classes |
| Deoxyadenosine | HMDB0000101 | ↓ | ↓↓ | PLS-DA-2classes |
| Deoxycytidine | HMDB0000014 | ↓ | ↓↓ | ANOVA, PLS-DA-3classes |
| Glycerol | HMDB0000131 | ↓ | ↑ | ANOVA, PLS-DA-3classes |
| Homogentistic acid | HMDB0000130 | ↓ | ↑ | ANOVA |
| Isoleucine | HMDB0000172 | ↓ | ↓↓ | ANOVA, PLS-DA-3classes |
| Lactose | HMDB0000186 | ↓ | ↑ | PLS-DA-2classes |
| Leucine | HMDB0000687 | ↓ | ↓↓ | PLS-DA-3classes |
| Malic acid | HMDB0000156 | ↓ | ↓↓ | ANOVA |
| N-acetyl glucosamine | HMDB0000803 | ↓↓ | ↓ | ANOVA, PLS-DA-3classes |
| Palmitic acid | HMDB0000220 | ↓↓ | ↓ | ANOVA |
| p-hydroxyphenylacetic acid | HMDB0000020 | ↓ | ↑ | ANOVA, PLS-DA-3classes |
| Pyroglutamic acid | HMDB0000267 | ↓ | ↓↓ | PLS-DA-2classes |
| Rhamnose | HMDB0000849 | ↓ | ↓↓ | ANOVA, PLS-DA-3classes PLSDA-2classes |
| Scyllo-inositol | HMDB0006088 | ↓ | ↑ | PLS-DA-2classes |
| Sebacic acid | HMDB0000792 | ↓ | ↑ | PLS-DA-2classes |
| Sorbose | HMDB0001266 | ↓↓ | ↓ | ANOVA |
| Succinic acid | HMDB0000254 | ↓ | ↑ | ANOVA, PLS-DA-2classes |
| Tagatose | HMDB0003418 | ↓↓ | ↓ | ANOVA, PLS-DA-3classes |
| Threonic acid | HMDB0000943 | ↓ | ↑ | PLS-DA-2classes |
| Threonine | HMDB0000167 | ↓ | ↑ | ANOVA |
| Tyrosine | HMDB0000158 | ↓ | ↑ | PLS-DA-3classes |
| Valine | HMDB0000883 | ↓ | ↓↓ | PLS-DA-3classes |
| Xylose | HMDB0000098 | ↓ | ↓↓ | ANOVA, PLS-DA-3classes PLSDA-2classes |
| γ-Aminobutyric acid | HMDB0000112 | ↓ | ↓ | PLS-DA-2classes |
↑ increased or ↓ decreased compared to healthy controls; ↓↓ decreased compared to both healthy controls and the other AN subtype. Differences were statistically significant for those metabolites selected by analysis of variance (ANOVA). PLS-DA = partial least square discriminant analysis; ANR = restricting type anorexia nervosa; ANBP = binge-purging type anorexia nervosa.