Table 4.

Studies on the use of BoNT-A therapy in pompholyx.

First Author [Ref.], year	Type of Study	n	BoNT-A Doses/Hand	Follow-Up	Retreatment	Results
Ismail [102], 2020	Prospective non-randomized side-by-side comparative study	40	100	1, 4, 6 months	No	Improvement
Kontochristopoulos [101], 2007	Case reports	2	4.0 mL saline in 100 U BoNT-A; 100 U/hand	8 weeks	No	Improvement
Swartling [96], 2002	Prospective	10	1.0 mL saline in 100 U BoNT-A; mean of 162 U/hand	28–59 days	No	7 of 10 patients reported a good result; improving in VAS for itching and disease activity score
Wollina [100], 2002	Prospective; side-by-side monotherapy with topical steroid vs. adjuvant BoNT-A injection	6	2.0 mL saline in 100 U BoNT-A	8 weeks	No	Six of 6 hands treated with topical steroids in combination with BoNT-A showed improvement; BoNT-A showed a more rapid release from itching than steroids alone