Table 7.

Studies on the use of BoNT-A in notalgia paresthetica.

First Author [Ref.], year	Type of Study	n	BoNT-A Doses	Retreatment	Follow-Up	Results
Maari [126], 2014	RCT vs. placebo double-blind	20	max 200 U	No	12 weeks, then placebo arm shifted to BoNT-A; total 24 weeks	No significant difference for pruritus (VAS) and hyperpigmentation
Pèrez-Pèrez [57], 2014	Retrospective, case series	5	48–56 U	No	18 months	2 worsening pruritus, little improvement in other 3 but for only 1 month
Wallengren [125], 2010	Prospective	6	18–100 U	No	18 months	5/6 patients a mean reduction of VAS by 28% at week 6; at 18 months 1 patient had a VAS of 45%, another one was still free from itch
Weinfeld [124], 2007	Case report	2	16–24 U	Yes, 18 months later with 48 U (only 1 patient)	18 months	Improvement (patient self-assessment)