Table 8.
Cases of Hailey–Hailey disease treated with BoNT-A.
| First Author [Ref.], year | n | Sites | BoNT-A Doses | Follow-Up | Results |
|---|---|---|---|---|---|
| Lapiere [131], 2000 | 1 | Axillae | 25 U, 50 U of per axilla after 6 months | 4 months at time of publication | Complete remission |
| Kang [129], 2002 | 1 | Groin, axillae | 100 U for each inguinal fold | 6 months | Improvement |
| Lopez-Ferrer [134], 2012 | 3 | Axillae groin breast, axilla, axillae and groin | 80 U/axilla 200 U total | 5 months | All patients improved but needed at least one retreatment after 1–3 months |
| Charlton [135], 2017 | 1 | Axillae and groin |
50 U for axillae 50 U for groin Once a year |
2 years | This therapy has restricted his disease activity to 1–2 episodes per year |
| Kothapalli [136], 2018 | NA | Axillae and groin |
50 units per axilla or groin | NA | Improvement |