Zanchi [178], 2008 |
Observational, no RCT |
15 (inverse psoriasis) |
50-100 U |
Not reported |
12 weeks |
Improvement in VAS scale score; photographic assessment with improvement of erythema, infiltration (87%) |
Saber [181], 2011 |
Case report |
1 (inverse psoriasis and hyperhidrosis) |
100 U per axilla |
No |
4 weeks |
Greatly improved (photographic documentation) |
Gilbert [182], 2014 |
Case report |
1 (plaque psoriasis) |
30 U for a single plaque |
No |
8 months |
Complete remission but recurrence after 8 months. |
Todberg [186], 2018 |
Exploratory, multicenter, randomized double-blinded trial (BoNT-A vs. vehicle). |
8 (plaque psoriasis) |
36 U for a single plaque |
No |
8 weeks |
No clinical or histological differences from the vehicle |
Aschenbeck [179], 2018 |
Open-label pilot study |
8 (plaque psoriasis) |
Variable number of units per plaque (average units, 53; range, 25–92) |
No |
10 weeks |
PASI and BSA reduction |
González [185], 2018 |
Descriptive cross-sectional study |
8 (plaque psoriasis) |
Variable number of units per plaque (maximum 50 U) |
No |
4 weeks |
All parameters evaluated (desquamation, erythema and infiltration) for TCS score showed improvement |