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. 2021 Feb 5;13(4):643. doi: 10.3390/cancers13040643

Table 2.

Multivariate analysis of factors associated with objective response.

OR (95%CI) p Value
Model 1: Rbinap
Lung primary (vs. other locations) 0.70 (0.21–2.38) 0.570
SCNEC (vs. NET or LCNEC) 8.89 (2.26–30.4) 0.001
Rbinap (vs. Rbapp) 1.70 (0.54–5.37) 0.368
Ki-67 (each additional 1%) 1 50.97–1.02) 0.550
Model 2: Rb < 150
Lung primary (vs. other locations) 0.70 (0.20–2.41) 0.566
SCNEC (vs. NET or LCNEC) 7.83 (2.25–27.28) 0.001
Rb < 150 (vs. Rb score ≥ 150) 4.16 (1.11–15.53) 0.034
Ki-67 (each additional 1%) 0.99 (0.96–1.01) 0.309
Model 3: p16high
Lung primary (vs. other locations) 0.71 (0.21–2.47) 0.602
SCNEC (vs. NET or LCNEC) 7.63 (2.19–26.57) 0.001
p16high (vs. p16low) 1.61 (0.47–5.56) 0.449
Ki-67 (each additional 1%) 1 (0.97–1.02) 0.804

LCNEC, large-cell neuroendocrine carcinoma; NEN, neuroendocrine neoplasm; NET, neuroendocrine tumor; OR, odds ratio; SCNEC, small-cell neuroendocrine carcinoma.