Table 1.

Biological functions of Pirin.

Model	Function	Description	Reference
Human	Enzymatic	Quercetinase activity	[13]
Prokaryote	Co-Enzymatic	Inhibition of acetyl-CoA catabolism	[15]
Human	Transcriptional regulator	Interaction with NF-I/BCL-3/NF-κB p50	[11]
Human	Transcriptional regulator/Redox sensor	Binding to NF-κB p65 in oxidative conditions	[22]
Human	Transcriptional regulator	Fe active form favors its binding and regulation to NF-κB/DNA	[23,24]
Plants	Transcriptional regulator/Redox sensor	Regulation of oxidative pathways and cell death and redox sensor	[26]
Animal	Redox sensor	Activation in superoxide dismutase (Sod1)-deficient mice	[27]

Abbreviations: NF-I: nuclear factor I; BCL-3: B-cell lymphoma 3-encoded protein; NF-κB: nuclear factor kappa B.