Figure 1.

Summary of known genetic aberrations in classic Hodgkin lymphoma (cHL) arranged according to aberration type and color-coded according to the affected cellular process that they dysregulate in Hodgkin and Reed-Sternberg cells; genes encoding for proteins related to apoptosis are in red, to B-cell identity—in brown, to cytokine (mainly JAK-STAT) signaling—in orange, to NF-κB signaling—in green, to immune escape—in blue, and to cytokinesis, chromatin/DNA/RNA functions—in black; inactivating translocations of SOCS1 that are characteristic of pediatric cHL [13] are not sown.