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. 2021 Feb 8;13(4):682. doi: 10.3390/cancers13040682

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) PDL1 overexpressing Hodgkin and Reed-Sternberg (HRS) cells in a case of PDL1/2 amplified classic Hodgkin lymphoma (cHL). (B) HRS cells expressing phosphorylated (p) JAK2 in a JAK2 rearranged cHL (insert with split red and green FISH signals corresponding to the rearranged allele and one fused yellow signal corresponding to the wild type allele of the JAK2 gene in the respective large HRS cell-equivalents utilizing a break-apart JAK2 probe). (C) pSTAT6 overexpressing HRS cells in a case of STAT6-mutated cHL. (D) Expression of pSTAT6 only in a few HRS cells as compared to. (E) pSTAT5 and, particularly, pSTAT3. (F) in a case of SOCS1-mutated cHL.