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. 2021 Feb 7;13(4):669. doi: 10.3390/cancers13040669

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Two approaches towards discovering drug vulnerabilities using CRISPR-Cas9 genome-wide screens: vulnerabilities that are derived from a specific genetic contexts (a) and drug-related vulnerabilities (b).