Figure 2.

NOX4 regulates tuberculosis-induced lung cancer cell migration and invasion: Scratch-wound healing assay and Transwell assay showed thatNOX4 downregulation significantly prevented the migration and invasion of lung cancer cells. In the Transwell assay, lung cancer cells were platedin the upper chamber containing Matrigel, and the conditioned medium of PMCs (pleural mesothelial cells) with or without HKMT treatment as the chemoattractant in the lower chamber was used for 48 h.(A)Mouse model: mouse PMCs and KLN205 lung cancer cells were used. (B) Human model: human PMC Met5A cells and A548 lung cancer cells were used. Data are presented as the mean ± SEM of at least three independent experiments. *** p < 0.001.