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. 2021 Feb 8;13(4):687. doi: 10.3390/cancers13040687

Figure 6.

Figure 6

Schematic illustrations of the mechanism by which tuberculous fibrosis contributes to the malignant potential of lung cancer. (A) TB-infected PMCs exhibited increased expression of NOX4. NOX4 downregulates autophagy signaling and induces TGF-β, IL-6, and TNF-α, leading to cancer cell proliferation. In lung cancer cells after exposure to TB-infected PMCs, NOX4 signaling increases and autophagy signaling decreases. (B) Knockdown of NOX4 in TB-infected PMCs increases autophagy signaling and reduces TGF-β, IL-6, and TNF-α, leading to cancer suppression.