Figure 1.

Cancer Immunity Cycle. Innate immune cells facilitate the immune system’s response against a recognized pathogen. This process is initiated by detection of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) and other unique tumor antigens by innate immune cells which result in antigen presentation and activation of antigen-specific T cells in tumor draining lymph nodes. These T cells traffic to the tumor and mediate tumor elimination. Abbreviations: PAMPs, pathogen-associated molecular patterns; DAMPs, damage-associated molecular patterns; PRRs, pattern-recognizing-receptors.