Table 6.
Complications of 10 consecutive uterus transplant recipients regarding infection, leukopenia, rejection and renal impairment.
| Case | Donor | CMV D/R |
Infection | Leukopenia | HLA m/m |
PRA | Rejection | CKD |
|---|---|---|---|---|---|---|---|---|
| 1 | LD1 | +/+ | Recurrent UTI, CMV replication day 1172 | 2/1 | 0% | Gr 1, day 459, MP Gr 1–2, day 1053, MP, ATG, AZA Gr 1, day 1270, TAC elev. |
G3A, day 27 | |
| 2 | DD1 | +/+ | N/A, graft loss day 7 | 4/2 | 0% | |||
| 3 | DD2 | +/+ | Recurrent UTI, Ureaplasma 1157 | Day 40, 156, 189 (aBM), 1066 | 4/1 | 3% | Gr 1, day 19, MP Gr 1, day 372, MP, AZA Gr 2–3, day 930, MP, AZA, ATG |
|
| 4 | LD2 | +/- | 1/1 | 0% | G2, d. 104 | |||
| 5 | DD3 | +/+ | Cl.difficie day 502 | Day 89, 95, 109, 115 (aBM), 473, 523 | 3/1 | 0% | Gr 1, day 13, MP Gr 1, day 193, MP Gr 1, day 367, AZA |
Prerenal day 502 |
| 6 | LD3 | +/- | UTI, CMV replication day 374, EBV replication day 1017 | Day 88 | 1/1 | 0% | Gr 2, day 150, MP Gr 3, day 197, ATG |
Prerenal day 68 |
| 7 | DD4 | +/+ | UTI, graft HSV infection day 40, graft loss day 213 | Day 72 | 3/2 | 7% | Protracted rejection in explant | |
| 8 | LD4 | +/+ | N/A, graft loss day 15 | 2/1 | 10% | |||
| 9 | LD5 | +/+ | 1/1 | 0% | Gr 2–3, day 395, MP, AZA Gr 1–2, day 415, MP |
|||
| 10 | DD5 | +/+ | CMV replication on day 547 | Day 50 | 2/2 | 7% | Gr 2, day 105, MP, AZA | |
| Mean ± SD | 2.3/1.3 |
Abbreviations: antithymocyte globuline (ATG), aspiration of bone marrow (aBM), azathioprine (AZA), cytomegalovirus (CMV), day (d.), decesased donor (DD), Epstein–Barr virus (EBV), grade (gr, G), herpes simplex virus (HSV), human leukocyte antigen (HLA) class I/II mismatch (HLA m/m), live donor (LD), methylprednisolone (MP), not applicable (N/A), pre-transplant panel-reactive antibodies (PRA), standard deviation (SD), tacrolimus (TAC) and urinary tract infection (UTI).