Table 2.
LncRNAs role and mechanisms in adaptive immunity.
| lncRNA | Model | Function | Main Results | References |
|---|---|---|---|---|
| GAS5 | T-cells. Leukemic T-cells | Involved in mTOR (mammalian target of rapamycin ) and glucocorticoid response pathways | Required for mTOR antagonist response in leukemic T cells and represses growth arrest and starvation induced by glucocorticoid receptor | [96,97] |
| lincR-Ccr2-5′AS | Different T-cells subsets especially TH2(T-Helper) | Correlated with chemokine response | Positive correlation with Ccr1,2,3 and 5 genes. Increases CD45+ cells migration | [50] |
| lncRNA Rmrp | TH17 | Correlated with cytokines response | Direct correlation with IL17a and f expression | [98] |
| NeST | CD8+ T cells | Correlated with INF-γ response | Prevents Theiler’s virus clearance, stimulates INF- γ response | [99,100,101] |
| NRON | Jurkat | Correlated with NFAT-dependent genes | IL-2 production negatively correlated with the lncRNA after stimulation | [102] |
| NTT | Human monocytic cells, macrophages and THP-1 | Involved in macrophages differentiation | C/EBPbeta/NTT/PBOV1 axis increases inflammatory status | [103] |