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. 2021 Feb 9;22(4):1728. doi: 10.3390/ijms22041728

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Photodynamic effect of virus nanoparticles carrying antitumor drugs. By regulating the self-assembly process of protein-like virus particles (VLPs), the fluorescent dye ICG can be loaded into a positively charged cavity to prepare RGD-HBc/ICG VLPs, thereby improving the stability of ICG, extending its circulation time in the body and effectively delivering it to the tumor. Under 808 nm near-infrared laser irradiation, RGD-HBc/ICGVLPs can produce photothermal/photodynamic effects and significantly eliminate tumor tissue in mice. ICG: indocyanine green; HBc VLP: hepatitis B core protein virus-like particle; RGD: tripeptide Arg-Gly-Asp.