Domain structure of mTOR and components of mTORC1 and mTORC2. DEPTOR, DEP domain-containing mTOR-interacting protein; FAT, FRAP/ATM/TRRAP; FATC, FRAP/ATM/TRRAP/Carboxy terminal; FKBP-12, FK506-binding protein-12; FRB, FKBP12-rapamycin-binding; HEAT, Huntingtin/Elongation factor 3/A subunit of protein phosphatase-2A/TOR1; mLST8, mammalian lethal with SEC13 protein 8; mSIN1, mammalian stress-activated protein kinase interacting protein 1; mTOR, mechanistic target of rapamycin; mTORC1, mTOR complex 1; mTORC2, mTOR complex 2; PRAS40, proline-rich AKT substrate 40 kDa; Protor, protein observed with RICTOR; RAPTOR, regulatory-associated protein of mTOR; RICTOR, rapamycin-insensitive companion of mTOR. The picture was modified from [53].