Skip to main content
. 2021 Feb 9;22(4):1743. doi: 10.3390/ijms22041743

Table 5.

Genetic alterations of MTOR in human cancers.

Primary Tumor Tissues Mutations (%) 1 Copy Number Variations (%) 1 Gene Expression (%) 1
Gain Loss Over Under
Adrenal gland 0/658 (0%) - 4/267 (1.5%) 1/79 (1.27%) -
Autonomic ganglia 0/1225 (0%) - - - -
Biliary tract 51/1388 (3.67%) - - - -
Bone 3/725 (0.41%) - - - -
Breast 258/7666 (3.37%) 1/1492 (0.07%) 2/1492 (0.13%) 39/1104 (3.53%) 32/1104 (2.9%)
– ductal carcinoma 120/2483 (4.83%) - - - -
– ER-positive carcinoma 29/1363 (2.13%) - - - -
– HER-positive carcinoma 8/205 (3.9%) - - - -
– basal (triple-negative) carcinoma 5/372 (1.34%) - - - -
ER-PR-positive carcinoma 6/308 (1.95%) - - - -
Central nervous system 56/3499 (1.6%) 1/1035 (0.1%) - 21/697 (3.01%) 91/697 (13.06%)
Cervix 21/388 (5.41%) - - 18/307 (5.86%) 5/307 (1.63%)
Endometrium 103/988 (10.43%) - - 27/602 (4.49%) 9/602 (1.5%)
– endometrioid carcinoma 82/649 (12.63%) - - 23/545 (4.22%) -
Eye 3/179 (1.68%) - - - -
Hematopoietic and lymphoid 118/6030 (1.96%) - - 2/221 (0.9%) 5/221 (2.26%)
Kidney 165/2998 (5.5%) - - 20/600 (3.33%) 12/600 (2%)
Large intestine 344/4526 (7.6%) - 1/718 (0.14%) 16/610 (2.62%) 35/610 (5.74%)
Liver 175/2381 (7.35%) - - 5/373 (1.34%) -
Lung 228/4930 (4.62%) 3/1006 (0.3%) 2/1006 (0.2%) 44/1019 (4.32%) 17/1019 (1.67%)
– adenocarcinoma 126/2724 (4.63%) 1/375 (0.27%) 1/375 (0.27%) 23/378 (6.08%) 12/378 (3.17%)
– non-small cell carcinoma 4/124 (3.23%) - - - -
– squamous cell carcinoma 44/1004 (4.38%) 1/500 (0.2%) 1/500 (0.2%) 11/502 (2.19%) 5/502 (1%)
Meninges 57/306 (18.63%) - - - -
Esophagus 79/1673 (4.72%) 1/510 (0.2%) - 5/125 (4%) -
Ovary 63/1396 (4.51%) 1/684 (0.15%) - 26/266 (9.77%) 11/266 (4.14%)
Pancreas 83/2505 (3.31%) - - 6/179 (3.35%) 10/179 (5.59%)
Penis 2/17 (11.76%) - - - -
Peritoneum 1/43 (2.33%) - - - -
Pituitary 0/89 (0%) - - - -
Pleura 0/470 (0%) - - - -
Prostate 217/3317 (6.54%) - 1/949 (0.11%) 14/498 (2.81%) -
Salivary gland 7/410 (1.71%) - - - -
Skin 236/2248 (10.5%) 2/587 (0.34%) - 39/473 (8.25%) 24/473 (5.07%)
Small intestine 5/252 (1.98%) - - - -
Soft tissue 18/1489 (1.21%) - - - -
Stomach 124/1912 (6.49%) 2/472 (0.42%) - 18/285 (6.32%) 4/285 (1.4%)
Testis 9/662 (1.36%) - - - -
Thymus 0/173 (0%) - - - -
Thyroid 42/2131 (1.97%) - - 20/513 (3.9%) 7/513 (1.36%)
Upper aerodigestive tract 44/1836 (2.4%) - - 26/522 (4.98%) 5/522 (0.96%)
Urinary tract 72/1209 (5.96%) - - 34/408 (8.33%) 2/408 (0.49%)
Vulva 1/30 (3.33%) - - - -

1 Mutated samples/total number of sample analyzed (%); -, no data. The data were derived from COSMIC v92 (released 27-AUG-20).