Table 1.
Clinical and pathological risk factors for recurrence [38].
| Clinical Risk Factors for Recurrence | |
|---|---|
| Size and location of lesion * | ≥20 mm on area L ≥10 mm on area M ≥6 mm on area H |
| Undefined borders | |
| Recurrent lesion | |
| SOTRs ** | |
| Previous radiotherapy or site of chronic inflammation | |
| Rapidly growing lesion | |
| Neurological symptoms | |
| Pathological risk factors for recurrence | |
| Not clearly differentiated lesion | |
| Adenoid, adenosquamous, or desmoplastic subtypes | |
| Clark level ≥IV | |
| Modified Breslow thickness ≥4 mm | |
| Perineural and/or vascular involvement |
* Area H: high risk of recurrence mask areas of face, ears, genitalia, hands, and feet; area M: middle risk of recurrence, cheeks, forehead, neck, and scalp; area L: low risk of recurrence, trunk and extremities. ** SOTRs, solid organ transplant recipients.