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. 2021 Feb 9;13(4):711. doi: 10.3390/cancers13040711

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Overview of major natural killer (NK) cell activating and inhibitory receptors and their corresponding ligands expressed on tumor cells. KIR: killer cell immunoglobulin-like receptors; NKG: natural killer receptor; TRAIL: tumor necrosis factor-related apoptosis-inducing ligand; NCR: natural cytotoxicity receptors; HLA: human leukocyte antigen; MICA: MHC class I polypeptide–related sequence; PVR: poliovirus receptor; DR5: death receptor 5; DNAM1: DNAX Accessory Molecule-1, ULBP1-6: UL16 binding protein 1-6, LLT-1: lectin-like Transcript-1.