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Synthesis of γ-lactones 11 and 2-hydroxyglutaric acid derivatives 12 from Passerini adducts 7.
| Entry | 1 (Ar) | 3 (R) | 7 (%) a | 11 (%) a | 12 (%) a |
|---|---|---|---|---|---|
| 1 | 1a (C6H5) | 3a (cC6H11) | 7a (93) | 11a (71) | 12a (80) |
| 2 | 1a (C6H5) | 3b (nC4H9) | 7b (84) | 11b (68) | 12b (99) |
| 3 | 1a (C6H5) | 3c (tC4H9) | 7c (87) | 11c (70) | 12c (99) |
| 4 | 1b (4-FC6H4) | 3a (cC6H11) | 7d (86) | 11d (73) | 12d (98) |
a Isolated yield.
