Table 1.
Major non-coding RNAs (miRNAs and long non-coding (lnc)RNAs) and their ECM/EMT-related targets.
| Non-Coding RNAs | Major Affected ECM/EMT Mediators |
|---|---|
| miRNAs | |
| miR-7 | Fibronectin; interleukin-1β |
| miR-9 | CDH1; β-catenin; VEGF; MYC |
| miR-10b | HOXD10; uPA/uPAR; syndecan-1; Twist; CDH1; vimentin; fibronectin; Snail2/Slug; IGF-IR; HER2; VEGF; MMP-2,-7,-9,-14 |
| miR-21 | PTEN; TIMP1; TIMP3; PDCD4; PI3K/AKT |
| miR-145 | CDH1; vimentin; fibronectin; Snail2; HER2; MMP-2,-9,-11; Rab GTPase family 27a |
| miR-152 | CDH1; DNMT1/DNMT3A |
| miR-199a-5p | CDH1; ZEB1; Twist |
| miR-200b | CDH1; vimentin; Snail2/Slug; fibronectin; ZEB1/2; BMI1; MMP-2,-7,-9,-14; Erk1/2; ERα/β |
| miR-203 | Snail2/Slug |
| miR-205 | Laminin gamma 1; CDH1 |
| miR-206 | VEGF; MAPK3; SOX9 |
| miR-211 | CDC25B; MMP-9 |
| miR-214 | PTEN-PI3K/AKT; collagen type IV alpha 1 |
| miR-221/222 | CDH1; Snail1; Snail2/Slug |
| miR-223 | CD44; TRAIL |
| miR-378 | Runx1 |
| miR-603 | eEF2K; IGF-IR |
| miR-4417 | EGFR; IGF-IR; cyclin D1; CDH1; vimentin; p38 MAPK |
| Long non-coding RNAs | |
| HAS2-AS1 | HAS2 |
| HOTAIR | HOXA9; PTEN; AR |
| LINK-A | HIF1α; EGFR |
| SNHG12 | MMP-13 |
| SKAI1BC | KAI1 |
| Aim, PVT1 | KLF5; β-catenin |
| LINC01638 | Twist; metadherin |
| MIR100HG | CDK18; WEE1; CCNF; CDKN1B; CDC25A |
| AWPPH | FZD7 |
| POU3F3 | Caspase 9 |
| ZEB2-AS1 | ZEB2 |
| LINC01638 | c-Myc; Twist1 |
| MIR503HG | Olfactomedin 4; MMP-9 |
Abbreviations: AR, androgen receptor; EGFR, epidermal growth factor receptor; FZD7, frizzled homolog 7; HER2, human epidermal growth factor receptor 2; IGF-IR, insulin-like growth factor receptor; MAPK, mitogen-activated protein kinase; PDCD4, programmed cell death protein 4; PTEN, phosphatase and tensin homolog; SOX9, SRY-Box transcription factor 9; VEGF, vascular endothelial growth factor.