Table 2.
Disease-free survival univariate analysis.
| Risk Factor at Surgery | Events/At Risk | HR (95% CI) | p-Value | |
|---|---|---|---|---|
| Age | 65/342 | 1.17 a (0.99–1.38) | 0.07 | |
| Tumor Size | 65/342 | 1.21 b (1.04–1.40) | 0.01 | |
| Hemoglobin | 65/342 | 0.84 c (0.72–0.97) | 0.02 | |
| RDW% | 65/342 | 1.16 c (1.05–1.28) | 0.003 | |
| HRR | ||||
| Continuous | 65/342 | 0.15 c (0.05–0.50) | 0.002 | |
| Median cut-off | <1.01 | 44/170 | 1 | |
| ≥1.01 | 21/172 | 0.41 (0.25–0.68) | <0.001 | |
| pN | N0 | 23/204 | 1 | |
| N1 Single Station | 15/55 | 3.30 (1.78–6.11) | <0.001 | |
| N1 Multiple Stations | 5/12 | 6.47 (2.37–17.7) | <0.001 | |
| N2 Single Station | 12/54 | 1.79 (0.87–3.67) | 0.12 | |
| N2 Multiple Stations | 19/17 | 9.25 (3.57–24.0) | <0.001 | |
| N Status d | Single station | 27/109 | 1 | |
| Multiple stations | 15/29 | 2.84 (1.43–5.63) | 0.003 | |
| Gender | Female | 27/161 | 1 | |
| Male | 38/181 | 1.23 (0.76–1.98) | 0.41 | |
| Smoker | No | 12/75 | 1 | |
| Yes | 53/264 | 0.85 (0.49–1.49) | 0.58 | |
| Surgery | Open | 42/188 | 1 | |
| Minimal Invasive Surgery | 23/154 | 0.66 (0.41–1.06) | 0.08 | |
| pN | N0 | 23/204 | 1 | |
| N1 | 20/67 | 3.69 (2.10–6.48) | <0.001 | |
| N2 | 22/71 | 2.85 (1.55–5.27) | <0.001 | |
| pT | pT1 | 12/136 | 1 | |
| pT2 | 35/141 | 2.22 (1.18–4.18) | 0.01 | |
| pT3 | 13/46 | 3.01 (1.35–6.71) | 0.007 | |
| pT4 | 5/19 | 3.33 (0.99–11.2) | 0.05 | |
| Grading | 0 | 4/22 | 1 | |
| 1 | 0/20 | Not estimable | - | |
| 2 | 22/159 | 0.74 (0.26–2.16) | 0.58 | |
| 3 | 30/112 | 1.80 (0.62–5.25) | 0.28 | |
| Stage | 1A,1B | 16/169 | 1 | |
| 2A,2B | 17/71 | 2.00 (1.08–3.69) | 0.03 | |
| 3A,3B | 32/102 | 3.72 (2.06–6.69) | <0.001 | |
| Treatments | No | 32/217 | 1 | |
| Yes | 33/121 | 1.67 (1.02–2.73) | 0.04 | |
| Procedure | Lobectomy | 60/318 | 1 | |
| Pneumonectomy | 5/24 | 1.99 (0.74–5.37) | 0.17 |
a by five-year increase; b by 10 mm increase; c by one unit increase; d N1 and N2 patients subgroup only; median follow-up = 13 months.