Fig. 3.

In vivo inhibition of CHIKV using α-Mangostin. a The reduction in CHIKV RNA copies/ml in serum and b copies/mg muscle tissue of C57/BL6 mice. Mice were infected with CHIKV by intramuscular route and viral RNA copies were assessed in serum and muscles on the 3rd, 5th and 7th day post infection. Two doses of α-Mangostin 20 mg/kg and 40 mg/kg were administered at 1, 2 and 3 dpi via the intraperitoneal route. Values are given as log₁₀ RNA copies/ml for serum and copies /mg for muscle tissue. Data shown are mean ± SD. ***p < 0.001; **p < 0.01 and *p < 0.05 vs. vehicle control