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. 2021 Feb 28;18:47. doi: 10.1186/s12985-021-01517-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Histopathological changes in mouse muscle tissues after chikungunya infection and α-mangostin treatment. C57BL/6 mice were infected with CHIKV. Hematoxylin and eosin-stained tissue sections were screened to investigate the therapeutic effects of α-mangostin treatment in CHIKV infected mice. PBS injected mice showed normal cellular organization. CHIKV infected muscles showed marked muscle degeneration, atrophy, MNC infiltration and edema (at day 3, 5 and day 7). Treatment with low dose α-Mangostin showed improvement in inflammatory signs in muscle tissue at 7th dpi compared to the VC group. High dose α-Mangostin treated mice muscle tissues showed the regeneration after treatment