Table 3.
Accuracy, sensitivity, and precision of the analytical method for the quantification of select PFAS and fluorinated alternatives in serum.a
| LOD | Precision | Accuracy (%) | |||||
|---|---|---|---|---|---|---|---|
| QCL | QCH | ||||||
| ng/mL | ng/mL | RSD (%) | ng/mL | RSD (%) | Low level | High level | |
| PFBS | 0.1 | 2.2 | 8.9 | 4.9 | 8.7 | 98±5 | 101±2 |
| PFHxS | 0.1 | 2.3 | 7.6 | 6.3 | 9.1 | 98±5 | 98±6 |
| PFHpS | 0.1 | 2.5 | 7.2 | 4.3 | 9.4 | 97±8 | 98±7 |
| n-PFOS | 0.1 | 5.4 | 13.3 | 11.2 | 9.3 | 99.7±6 | 97±2 |
| Sm-PFOS | 0.1 | 0.7 | 8.7 | 1.8 | 6.8 | 92±4 | 96±6 |
| PFHxA | 0.1 | 2.3 | 10.4 | 5.9 | 10.1 | 102±6 | 104±5 |
| PFHpA | 0.1 | 2.4 | 8.8 | 6.1 | 7.3 | 103±3 | 99±6 |
| n-PFOA | 0.1 | 2.5 | 12.7 | 6.7 | 8.2 | 105±5 | 101±2 |
| Sb-PFOA | 0.1 | 3.0 | 10.9 | 8.5 | 10.8 | 106±8 | 102±5 |
| PFNA | 0.1 | 2.3 | 10.6 | 6.5 | 9.0 | 103±7 | 102±3 |
| PFDA | 0.1 | 2.5 | 8.8 | 6.4 | 7.2 | 96±6 | 98±4 |
| PFUnDA | 0.1 | 2.4 | 10.2 | 6.7 | 6.5 | 105±3 | 97±4 |
| HFPO-DA | 0.1 | 2.3 | 7.4 | 6.4 | 9.8 | 97±4 | 98±5 |
| DONA | 0.1 | 2.4 | 8.2 | 6.4 | 8.5 | 96±5 | 94±5 |
| 9Cl-PF3ONS | 0.1 | 2.0 | 8.9 | 6.6 | 8.8 | 104±7 | 102±5 |
| FOSA | 0.1 | 2.1 | 10.8 | 6.5 | 8.9 | 100±5 | 98±2 |
| MeFOSAA | 0.1 | 1.7 | 11.7 | 7.8 | 9.3 | 93±5 | 101±3 |
| EtFOSAA | 0.1 | 1.1 | 11.8 | 5.0 | 8.1 | 98±8 | 102±2 |
a
We followed the approach used to analyze the 2013–2104 NHANES serum samples (https://www.cdc.gov/nchs/data/nhanes/nhanes_13_14/PFAS_H_MET.pdf)