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Genetic pathways of insulin resistance (PIP3: Phosphatidylinositol (3,4,5)-trisphosphate; aPKC: Activated protein kinase C; AKT1: Protein kinase B; GSK3: Glycogen synthase kinase 3; mTOR: mammalian target of rapamycin; FOXO1: Forkhead box protein O1; PDK1: 3-Phosphoinositide-dependent protein kinase 1; P: phosphorylated).
