NAFLD |
Non-alcoholic fatty liver disease |
MS |
Metabolic syndrome |
IR |
Insulin resistance |
CV |
Cardiovascular |
HDL |
High density lipoproteins |
FFAs |
Free fatty acids |
ER |
Endoplasmic reticulum |
PDFF |
Proton density fat fraction |
MRI |
Magnetic resonance imaging |
NASH |
Non-alcoholic steatohepatitis |
HCC |
Hepatocellular carcinoma |
T2DM |
Type 2 diabetes mellitus |
BMI |
Body Mass Index |
OGTT |
Oral glucose tolerance test |
HbA1c |
Glycated hemoglobin |
MAFLD |
Metabolic associated fatty liver disease |
IRS |
Insulin receptor |
PI3K |
Phosphatidylinositol 3-kinase |
GLUT-4 |
Glucose transporter protein type-4 |
TNF-α |
Tumor necrosis factor-alpha |
SREBP-1/2 |
Sterol regulatory element-binding protein-1/2 |
ChREBP |
Carbohydrate-responsive element-binding protein |
PPAR-γ |
Peroxisome proliferator-activated receptor gamma |
BA |
Bile acids |
LPS |
lipopolysaccharides |
SCFA |
Short-chain fatty acids |
ROS |
Reactive oxygen species |
O2•−
|
superoxidation radicals |
H2O2
|
Hydrogen peroxide |
NADPH |
Nicotinamide adenine dinucleotide phosphate hydrogen |
NF-κB |
Nuclear factor kappa B |
JNK |
Jun N-terminal kinase |
IKK |
Inhibitor of nuclear factor kappa-B kinase |
EASL |
European Association for the Study of Liver |
AASLD |
American Association for the Study of Liver Disease |
PUFA |
Polyunsaturated fatty acid |
MD |
Mediterranean diet |
MUFA |
Mono-unsaturated fatty acid |
IL |
Interleukin |
LDL |
Low density lipoprotein |
VLDL |
Very low density lipoprotein |
SNPs |
Single nucleotide polymorphisms |
PNPLA3 |
Patatin like phospholipase domain-containing protein 3 |
HSC |
Hepatic stellate cells |
LXR |
Liver X receptor |
MBOAT-7 |
Membrane Bound O-Acyltransferase Domain Containing 7 |
GCKR |
glucokinase regulatory protein |
TGF-1 |
Transforming growth factor beta 1 |
PDGF |
Platelet-derived growth factor |
HAT |
Histone acetyltransferase |
HDAC |
Histone deacetylases |
SIRT |
Sirtuins |
SFAs |
Saturated fatty acids |
EDHF |
hyperpolarizing factor of endothelial derivation |
ED |
endothelial dysfunction |
NOS |
Nitric oxide synthetase |
ESM-1 |
Endocan |
HMGB1 |
High mobility group box 1 protein |
CAD |
coronary artery disease |
HCV |
hepatitis C virus |
HBV |
hepatitis B virus |
US |
ultrasound |
CAP |
Control attenuation parameter |
IMT |
Intima-media thickness |
CKD |
Chronic kidney disease |
PIP3 |
Phosphatidylinositol (3,4,5)-trisphosphate |
aPKC |
activated protein kinase C |
AKT1 |
Protein kinase B |
GSK3 |
Glycogen synthase kinase 3 |
mTOR |
Mammalian target of rapamycin |
FOXO1 |
Forkhead box protein O1 |
PDK1 |
3-Phosphoinositide-dependent protein kinase 1 |
P |
phosphorylated |