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. 2021 Feb 10;22(4):1750. doi: 10.3390/ijms22041750
aa-AMP aminoacyl-adenylate
aaRS aminoacyl-tRNA synthetase
aa-tRNA aminoacyl-tRNA
aaS3DA aminoacyl sulfamoyl 3-deazaadenosine
aaSA aminoacyl-sulfamoyl adenosine
aaSoA 5′-(N-aminoacyl)-sulfonamido-5′-deoxyadenosine
aaSoHA N-L-aminoacyl-C-5′-adenosyl-methansulfonamide
AdT amidotransferase
AlaRS alanyl-tRNA synthetase
AMP adenosine monophosphate
AMPPNP adenylyl-imidodiphosphate
AMR antimicrobial resistance
AP auxiliary pocket
ArgRS arginyl-tRNA synthetase
AsnRS asparaginyl-tRNA synthetase
AspRS aspartyl-tRNA synthetase
ATP adenosine triphosphate
CP1 connective polypeptide 1
CysRS cysteinyl-RNA synthetase
DNA Deoxyribonucleic acid
EC50 half maximal effective concentration
EPRS glutamyl prolyl-tRNA synthetase
ESBL extended spectrum β-lactamase
FDA Food and Drug Administration
GlnRS glutaminyl-tRNA synthetase
GluRS glutamyl-tRNA synthetase
GlyRS glycyl-tRNA synthetase
GSA glycyl-sulfamoyl adenosine
GSK GlaxoSmithKline
HisRS histidyl-tRNA synthetase
HTS high-throughput screening
IC50 half maximal inhibitory concentration
IleRS isoleucyl-tRNA synthetase
ISA isoleucyl-sulfamoyl adenosine
ITC isothermal titration calorimetry
LeuRS leucyl-tRNA synthetase
LSA leucyl-sulfamoyl adenosine
LysRS lysyl-tRNA synthetase
McC microcin C
MDR multidrug resistance
MetRS methionyl-tRNA synthetase
MIC minimum inhibitory concentration
MRSA methicillin-resistant Staphylococcus aureus
Mtb Mycobacterium tuberculosis
PDB protein data bank
PheRS phenylalanyl-tRNA synthetase
PPi pyrophosphate
ProRS prolyl-tRNA synthetase
PylRS pyrrolysyl-tRNA synthetase
RF Rossmann fold
RNA ribonucleic acid
SAR Structure-activity relationship
SBDD structure-based drug design
SepRS phosphoseryl-tRNA synthetase
SerRS seryl-tRNA synthetase
SSA seryl-sulfamoyl adenosine
ThrRS threonyl-tRNA synthetase
Tm melting temperature
tRNA transfer RNA
TrpRS tryptophanyl-tRNA synthetase
TSA threonyl-sulfamoyl adenosine
TyrRS tyrosyl-tRNA synthetase
ValRS valyl-tRNA synthetase
WHO World Health Organization